Non-steroidal anti-inflammatory drugNimesil belongs to the class of sulfonamides. Pharmacological actions of the medicine are based on its antipyretic, analgesic, anti-inflammatory properties. Active active substance is nimesulide. The mechanism of its work is based on the inhibition of the enzyme cyclooxygenase, which is responsible for the synthesis of prostaglandins.

There are several medicinal forms of the drug"Nimesil". The description in the annotation contains information on its release in the form of granules for the preparation of solution, suspension, granules for the preparation of suspension, tablets (for resorption, dispersible and soluble for children).

The drug "Nimesil" has a good digestibility,it is easily absorbed through the LCD. In blood plasma the drug reaches its highest concentration within 3 hours, is excreted from the body by the kidneys (50%). The named pharmacokinetic properties of the Nimesil drug do not depend on the age of the patient, nor did the difference in nimesulide concentration parameters in healthy patients and patients with renal insufficiency.

In today's medicine, there are several indications, in which effective treatment is considered to be the drug "Nimesil". These include, in particular:

- rheumatism;

- osteoarthritis, Bekhterev's disease;

- tendonitis, synovitis, tendovaginitis;

- pain syndrome (posttraumatic, algodismenorea), bursitis;

- fever during infectious inflammation;

vertebral pain;

- myalgia, neuralgia;

- trauma of the musculoskeletal system, soft tissues.

There are conditions under which it is impossibletake medicine "Nimesil". Contraindications refer to cases in which there are hyperergic reactions due to the use of nimesulide and other NSAIDs. And with hepatotoxic reactions, treatment is also considered unacceptable. It is not recommended to combine therapy with this drug with the use of medications having the abovementioned reactions, for example, paracetamol and other analgesics. Intestinal inflammations of different genesis are also an obstacle for the administration of Nimesil. Contraindications concern postoperative period of aortocoronary shunting, fever accompanying inflammatory infections.

Care must be taken when:

- arterial hypertension (severe forms);

- IHD, heart failure;

- type 2 diabetes mellitus;

- diseases of peripheral arteries;

- Peptic ulcer disease;

- smoking;

- The elderly.

When these pathological processes are detectedIt is necessary to strictly follow the doctor's recommendations when treating with the drug "Nimesil". Contraindications to the use of this medication contain some serious illnesses, such as heart failure, blood clotting disorders, confirmed hyperkalemia, renal failure.

In any case, the decision to use thecontraindications play a significant role as a medicinal product of the drug "Nimesil". The purpose of this medication should be based on the individual characteristics of the patient according to the formula "risk-benefit".

It is not recommended to take this medication withdrug addiction and alcoholism, children under 12 years of age, pregnant and lactating women, if they find a high sensitivity to the drug.

At long reception, the maximal dosages,treatment with several drugs at the same time can have negative effects of treatment with a drug "Nimesil". Side effects are reflected in the system of hematopoiesis, central nervous system, cardiovascular, digestive, respiratory systems. There are allergic reactions, negative manifestations on the part of the organs of sight, and general malaises also occur. In such cases, it is necessary to reduce the dosage or stop treatment with the drug and seek advice from a specialist.

Long-term use of the drug "Nimesil" obliges to strict control over the function of the kidneys. Keep the medicine in a cool, inaccessible place, at tmax 25 ° C.